From Atlanta to Jesup begin on I-75 S to Macon taking I-16 E towards Savannah. Take US-1 S at exit 90. At Baxley take GA-341/27 E toward Jesup. Approximately 230 miles.

From Tallahassee to Jesup begin on I-10 E taking exit US 221 N and then US 84 E. Approximately 185 miles.

From Columbia to Jesup begin on begin on I-20 E taking exit 169 merge onto I-95 S. Take exit 87 and turn left onto US 17 S and right onto US 84 W. Approximately 215 miles.